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Infectious diseases

PODCAST : Trajectoires évolutives des virus : convergence, adaptation et dynamique

Pour son projet de thèse, Marie Morel cherche à mettre au point des méthodes de bioinformatique pour détecter des formes d’adaptation chez les virus et notamment dans un premier temps des mutations de convergence.  Les mutations de convergence sont des mutations qui apparaissent plusieurs fois au cours de l’évolution de manière indépendante. Elles ne sont donc pas héritées d’un ancêtre commun mais sont le fruit d’une même forme d’adaptation en raison de contraintes environnementales fortes.

Published in The Lancet. Infectious Diseases - 03/28/2019
Rindra Randremanana, PhD,a,* Voahangy Andrianaivoarimanana, PhD,b,* Birgit Nikolay, PhD,d,* Beza Ramasindrazana, PhD,b,* Juliette Paireau, PhD,d,* Quirine Astrid ten Bosch, PhD,d,* Jean Marius Rakotondramanga, MSc,a,* Soloandry Rahajandraibe, MSc,g Soanandrasana Rahelinirina, PhD,b Fanjasoa Rakotomanana, PhD,a Feno M Rakotoarimanana, MD,a Léa Bricette Randriamampionona, MD,h Vaoary Razafimbia, MD,h Mamy Jean De Dieu Randria, Prof, MD,i Mihaja Raberahona, MD,i Guillain Mikaty, PhD,e Anne-Sophie Le Guern, PharmD,f Lamina Arthur Rakotonjanabelo, MSc,j Charlotte Faty Ndiaye, Prof, MD,j Voahangy Rasolofo, PhD,c Eric Bertherat, MD,k,† Maherisoa Ratsitorahina, MD,h,† Simon Cauchemez, PhD,d,†* Laurence Baril, MD,a,† André Spiegel, MD,c,† and Minoarisoa Rajerison, PhDb,†

BACKGROUND:

Madagascar accounts for 75% of global plague cases reported to WHO, with an annual incidence of 200-700 suspected c

Published in The New England Journal of Medicine - 05/09/2019
Birgit Nikolay, Dr.rer.nat., Henrik Salje, Ph.D., M. Jahangir Hossain, M.B., B.S., A.K.M. Dawlat Khan, M.A., Hossain M.S. Sazzad, M.B., B.S., Mahmudur Rahman, Ph.D., Peter Daszak, Ph.D., Ute Ströher, Ph.D., Juliet R.C. Pulliam, Ph.D., A. Marm Kilpatrick, Ph.D., Stuart T. Nichol, Ph.D., John D. Klena, Ph.D., Sharmin Sultana, Ph.D., Sayma Afroj, Ph.D., Stephen P. Luby, M.D., Simon Cauchemez, Ph.D., and Emily S. Gurley, Ph.D.

Nipah virus is a highly virulent zoonotic pathogen that can be transmitted between humans.

Nipah outbreaks in Bangladesh: age and breathing difficulties of infected patients increase the risk of disease spread

Nipah virus, a bat-borne paramyxovirus found throughout South and South East Asia, has been identified by WHO as an emerging infectious disease that may cause severe epidemics in the near future. Infections in humans result in severe respiratory and neurological disease with a high case fatality. With no available treatment or vaccine, the control of Nipah virus outbreaks must rely on a detailed understanding of factors that may facilitate inter-human transmission.

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