Are the 7C psychological antecedents associated with COVID-19 vaccinebehaviours beyond intentions? A cross-sectional study on at-least-one-doseand up-to-date vaccination status, and uptake speed amo

Vaccine

Gaëlle Lièvre, Jonathan Sicsic, Simon Galmiche, Tiffany Charmet, Arnaud Fontanet,

Judith E. Mueller

Abstract

Background: Widely documented psychological antecedents of vaccination are confidence in vaccines, complacency, convenience, calculation, collective responsibility (5C model) with the recent addition of confidence in the wider system and social conformism. While the capacity of these seven antecedents (7C) to explain variance in COVID-19 vaccine intentions has been previously documented, we study whether these factors also are associated with vaccine behaviours, beyond intentions.

Methods: From February to June 2022, we recruited a sample of adults in France, including persons with notified recent SARS-CoV-2 infection, along with relatives and randomly selected non-infected persons. Participants completed self-administered questionnaires assessing COVID-19 vaccination history and the 7C antecedents. We defined vaccination behaviours as three outcomes: at-least-one-dose vaccine status by 2022 (N = 49,019), up-todate vaccination status (N = 46,566), and uptake speed of first dose (N = 25,998). We conducted multivariable logistic regressions and Cox models.

Results: Among the 49,019 participants, 95.0% reported receipt of at least one dose and 89.8% were up to date with recommendations. All 7C antecedents were significantly associated with the outcomes, although effects were weaker for up-to-date vaccination status and uptake speed. The strongest effects (most vs. least vaccinefavourable attitude level, at-least-one-dose vaccination status) were observed for collective responsibility (OR:

14.44; 95%CI: 10.72–19.45), calculation (OR: 10.29; 95%CI: 7.53–14.05), and confidence in the wider system (OR: 8.94; 95%CI: 6.51–12.27).

Conclusion: This study demonstrates that the 7C not only explain vaccine intention, but also vaccine behaviours, and underpins the importance of developing vaccine promotion strategies considering the 7C antecedents.

More information at 10.1128/mbio.01423-23