Determinants of bacterial survival and proliferation in blood

FEMS Microbiology Reviews

Pierre Lê-Bury, Hebert Echenique-Rivera, Javier Pizarro-Cerdá, Olivier Dussurget*

Abstract

Bloodstream infection is a major public health concern associated with high mortality and high healthcare costs w orldwide . Bac- teremia can trigger fatal sepsis whose prevention, diagnosis, and management have been recognized as a global health priority by the World Health Organization. Additionally, infection control is increasingly threatened by antimicrobial resistance , whic h is the focus of global action plans in the fr amew ork of a One Health r esponse. In-de pth knowledge of the infection process is needed to develop efficient pr ev enti v e and therapeutic measur es. The pathogenesis of b loodstr eam infection is a dynamic pr ocess r esulting fr om the invasion of the vascular system by bacteria, which finely regulate their metabolic pathways and virulence factors to overcome the b lood imm une defenses and pr olifer ate . In this re vie w, we highlight our current understanding of determinants of bacterial survi v al and proliferation in the bloodstream and discuss their interactions with the molecular and cellular components of blood.

More information at DOI: https://doi.org/10.1093/femsre/fuae013