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From dynamic chromatin architecture to DNA damage repair and back

Nucleus Emmanuelle Fabre and Christophe Zimmer

Nucleus. 2018; 9(1): 161–170. Published online 2018 Jan 30. doi: 10.1080/19491034.2017.1419847

PMCID: PMC5973241 PMID: 29271297 Abstract Maintaining the integrity of the genome in the face of DNA damage is crucial to ensure the survival of the cell and normal development. DNA lesions and repair occur in the context of the chromatin fiber, whose 3D organization and movements in the restricted volume of the nucleus are under intense scrutiny. Here, we highlight work from our and other labs that addresses how the dynamic organization of the chromatin fiber affects the repair of damaged DNA and how, conversely, DNA damage and repair affect the structure and dynamics of chromatin in the budding yeast nucleus.

KEYWORDS: homologous recombination, chromatin dynamics, chromatin structure, Polymer simulations, nuclear organization, Chromatin, Chromosome, DNA repair

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