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large-scale and user-friendly differential k-mer analyses

Updated: May 29, 2023


Téo Lemane, Rayan Chikhi, Pierre Peterlongo

Genome wide association studies elucidate links between genotypes and phenotypes. Recent studies point out the interest of conducting such experiments using k-mers as the base signal instead of single-nucleotide polymorphisms. We propose a tool, kmdiff, that performs differential k-mer analyses on large sequencing cohorts in an order of magnitude less time and memory than previously possible.

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